What Is the MTHFR Genetic Defect and How Can it Affect You?

Many news outlets, and indeed some pharmaceutical makers, lead us to believe that we are merely a product of our genes, but this isn’t true at all. In fact, studies on identical twins, who start out with identical genes, reveal that lifestyle is a much more powerful influence on health.^[1] So while your genes do play a role in the initiation and development of some diseases, you day-to-day choices largely determine how (or if) these genes can affect your life and health.

What Is the MTHFR Gene?

Genes are stretches of genetic information on your chromosomes that provide instructions to your body. The MTHFR gene provides the directions to produce an enzyme called methylenetetrahydrofolate reductase. This enzyme is responsible for many important processes such as amino acid balance, DNA synthesis, and repair, regulating gene expression, converting inactive folic acid or folate into the active form your body uses.

Note: The abbreviated MTHFR gene is often confused with the enzyme it codes for, methylenetetrahydrofolate, and the product the enzyme helps make, levomefolic acid (also called L-methylfolate and 5-methyltetrahydrofolate). For clarity, we will specify either the MTHFR gene, the MTHFR enzyme, or levomefolic acid throughout this article.

Effects on the Human Body

If you have an MTHFR mutation, an inability to process folic acid (vitamin B9) can have serious effects. A deficiency in B9 can cause a growing fetus to develop devastating neural tube defects like spina bifida or anencephaly. Folate deficiency can also result in lethargy, impaired cognitive function, and mood disorders.^{[1, 3]}

Active folate plays a vital role in amino acid conversion, specifically in the homocysteine to methionine cycle. Methionine is an essential amino acid required for producing glutathione, the body's primary antioxidant product. The liver converts methionine into SAM-e, a chemical that helps metabolize the neurotransmitters dopamine, serotonin, and melatonin. The brain needs methionine to produce myelin, a coating that covers your brain cells’ axons, to quickly transmit information and impulses. A defect in the MTHFR gene may promote high levels of homocysteine levels in your tissues, negatively affecting mental health and mood.^{[4, 5]}

B9 to Active Folate Conversion

The MTHFR enzyme converts inactive folate to the active form your cells need, levomefolic acid. Put more simply, this gene is responsible, in part, for converting vitamin B9 (folic acid) into a form your cells can use for metabolism. If you aren’t able to convert inactive B9 into levomefolic acid, the effects multiply as other metabolic processes are affected, and cellular processes slow to a halt. Depending on the severity of the variation, you might be completely unable to convert inactive B9 to its active form, or simply have a reduced capacity to do so.

Active folate is essential for cell division, heart function, DNA synthesis, DNA repair, eye health, brain function, memory, and proper fetal skeletal and brain development.^[6]

Elevated Homocysteine and Methylation

You need levomefolic acid to convert the amino acid homocysteine into other forms required by the body. Without this enzyme, homocysteine can build up in your blood and other tissues as you are unable to produce homocysteine-derived products like cysteine, methionine, and other necessary intermediaries you need for an assortment of metabolic processes.^[7]

Methylation, a process involving the transfer of a methyl group to another compound, is also associated with the MTHFR gene. Proper methylation enables the body to detoxify some potentially risky compounds generated by, or taken into, the body. Levomefolic acid is a universal methyl donor, which means it can safely transfer its methyl group to detoxify or otherwise modify compounds in your body. Methylation is particularly important in the brain.^[5]

As mentioned previously, a defect in the MTHFR gene can cause an abnormally high level of homocysteine in your tissues. High levels of homocysteine are associated with cardiovascular disease, high blood pressure, glaucoma, ischemic stroke, and atherosclerosis.^[3] Research links migraines and mental disorders such as schizophrenia, bipolar disorder, and depression to inadequate methylation resulting from variances in the MTHFR gene.^{[8, 9]}

Lifestyle Modifications and Solutions

Whether your doctor has determined that you have the MTHFR gene defect or you are experiencing similar symptoms related to the disorder, there are a few steps you can take to protect yourself from its effects.

You’ll find methionine in plant foods, like soy and beans, but it’s more concentrated in animal-based foods.^[10] There are many benefits to a plant-based diet, and it's typically what we recommend, but that's everyone's own choice. Further, make sure to avoid synthetic folic acid and exposure to environmental toxins which can tax the liver. Perform a liver cleanse at least twice a year to facilitate the removal of toxins and wastes. Finally, speak with your healthcare provider about methylated folate. This is the active form of folate that your body should convert B9 and it may be an important supplement to implement in your daily health regime.

†Results may vary. Information and statements made are for education purposes and are not intended to replace the advice of your doctor. If you have a severe medical condition or health concern, see your physician.

Dr. Edward Group, DC

FOUNDER | HEALER | ADVOCATE

Dr. Group, DC is a healer and alternative health advocate, and an industry leader and innovator in the field of natural health who is dedicated to helping others. He is a registered doctor of chiropractic (DC), a naturopathic practitioner (NP), and proud alum of Harvard Business School and MIT Sloan School of Management. Dr. Group, DC is the founder of Global Healing – a mission and vision he has shared through best-selling books and frequent media appearances. He aims to spread his message of positivity, hope, and wellness throughout the world.

Related Posts

Foods That Lower Blood Pressure

There is a virtual cornucopia of foods, herbs, and other forms of nourishment that are readily available to lower high blood pressure, or hypertension, naturally. Fruits, vegetables, and nuts are...

Top 10 Benefits of a Heavy Metal and Toxin Detox

When it comes to wellness, you already know that what you put into your body matters. But did you know that you can unintentionally consume things that could be detrimental...

Are All Detox Foot Pads A Scam?

I have recently been receiving many concerned e-mails and phone calls regarding the effectiveness of detox foot pads. Some reports are incorrectly stating that ALL detox foot pads are a...

14 Healthy Eating Tips (from our Facebook Fans)

Yesterday, we had a contest on our Facebook page. We asked everybody to share their favorite healthy eating tips with everybody, and the winners got a free T-Shirt and copy...

How to Make a Castor Oil Pack for Lung Cleansing

Castor Oil Packs have been used successfully over the years for lung cleansing. Castor oil has long been used as a folk remedy for a broad spectrum of ailments, including...

Deep Breathing for Lung Cleansing

Oxygen is, by far, the most vital component humans need to live. We can go weeks without food, days without water, but only a few minutes without air. To get...